anadrol for sale
The ingestion absorbed more than 70%. The absolute bioavailability due to the effect of “first pass” is reduced by 40%. After a single oral dose of 250 mg of the time to reach maximum concentration anadrol for sale about 2 hours; maximum concentration (Cmax) – 1 ug / ml. The area under the curve “concentration – time», while taking a meal increased by 20%. Chronic administration Cmax increased by 25%. The effective , terminal T1 / 2 h 200-400 (points to a long elimination of skin and adipose tissue). Equilibrium concentration is not dependent on age. The concentration of terbinafine in the plasma does not depend on the floor.
Relationship to plasma proteins – 99%. Is rapidly distributed to tissues, it penetrates into the dermal layer of skin and nail plate. It penetrates the sebum and accumulates in high concentrations in the hair follicles in hair, skin and subcutaneous tissue. Subject to significant biotransformation, the resulting metabolites do not possess antifungal activity. 70% of the kidneys. Not accumulates in the body. Age of the patients did not affect the pharmacokinetics of terbinafine, but elimination may be reduced in patients with lesions of the kidneys and liver, resulting in high concentrations of terbinafine in the blood.Provided with breast milk.
- Fungal infections of the scalp anadrol for sale (trihofitia, mikrosporiya).
- Fungal diseases of the skin and nails (onihompkozy) due Trychophyton spp. (T. rubrum, T. mcntagrophytcs, T. vcrrucosum, T. violaceum), Microsporum spp. (M. canis, M. gypscum) and Epidcrmophyton floccosum.
- Heavy, common ringworm smooth skin of the trunk and limbs requiring systemic treatment.
- Skin candidiasis.
Hypersensitivity to the drug; chronic or active liver disease, chronic renal insufficiency (creatinine clearance (CC) of less than 50 ml / min), children under 3 years of age and weighing up to 20 kg (for a given dosage form), during lactation, pregnancy.
Chronic renal failure (creatinine clearance greater than 50 mL / min), alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease.
Application of pregnancy and breastfeeding
Reception terbinafine during pregnancy is contraindicated because of the lack of sufficient information about its safety during pregnancy. Terbinafine is excreted in breast milk, so his appointment is contraindicated during breast-feeding.
Dosing and Administration
Inside, after a meal.
250 mg 1 time per day.
Children older than 3 years
When the body weight anadrol for sale of 20 to 40 kg – 125 mg 1 time per day.
With a body weight over 40 kg – 250 mg 1 time per day.
Older patients dose is not required correction.
Patients with chronic renal failure (creatinine clearance greater than 50 mL / min) – 125 mg 1 time per day.
The duration of treatment depends on the indication and the severity of the disease.
Fungal infections of the skin: the duration of treatment with interdigital, plantar or “sock” type of localization of infection is 2-6 weeks; when mycoses of other parts of the body: the shins – 2-4 weeks, the body – 2-4 weeks; in mycosis caused by fungi of the genus Candida – 2-4 weeks; with mycosis of the scalp – about 4 weeks after infection Microsporum canis – more than 4 weeks.
Onychomycosis: duration of treatment on average 6-12 weeks. With the defeat of nails of fingers and feet (with the exception of the big toe), or the young age of the patient treatment duration may be less than 12 weeks. Infection of the big toe is usually sufficient 3-month course of treatment. Some patients who have reduced the speed of nail growth, may require longer treatment.
The frequency of side effects is classified according to the recommendations of the World Health Organization: very often – at least 10%; often – at least 1% but less than 10%; infrequently – at least 0.1% but less than 1%; rare – less than 0.01% but less than 0.1%; very rarely – less than 0.01%, including isolated cases.
From the digestive system: very often – a sense of fullness, loss of appetite, indigestion, nausea, abdominal pain, diarrhea; infrequently – breach or loss of taste sensation (recovery occurs within a few weeks after cessation of treatment), increased activity of “liver” transaminases; rare anadrol for sale – cholestasis, jaundice, hepatitis; in some cases – long disorder of taste, leading to the abandonment of food intake and a significant decrease in body weight, liver failure.