When administered orally is well absorbed more than 70%, the absolute bioavailability due to the effect of “first pass” is about 50%. After a single oral dose of 250 mg of the time to reach maximum plasma concentration anadrol cycle is about 1.5 hours; maximum concentration . The area under the curve “concentration – time» (AUC) – 4.56 mkghch / ml, while receiving dietary AUC increased by 20%.Chronic administration of a terminal T 1/2 – 200-400 hours (prolonged indicates removal of skin and adipose tissue). Equilibrium concentration (Css) is not dependent on age. The concentration of terbinafine in the plasma does not depend on the floor.
Relationship to plasma proteins – 99%. Is rapidly distributed to tissues, it penetrates into the dermal layer of skin and nail plate. It penetrates into the secret of the sebaceous glands and accumulates in high concentrations in hair follicles, in volosach, skin and subcutaneous tissue. Subject to significant metabolism produced metabolites do not possess antifungal activity. 70% of the kidneys. Not accumulates anadrol cycle in the body. Age of the patients did not affect the pharmacokinetics of terbinafine, but elimination may be reduced in patients with lesions of the liver and kidneys, resulting in high concentrations of terbinafine in the blood. Provided with breast milk.
INDICATIONS FOR USE
Fungal infections of the scalp (trihofitia, mikrosporiya).
– Fungal diseases of the skin and nails (onychomycosis), due Trychophyton spp. (T. rubrum, T. mentagrophytes, T. verrucosum, T. violaccum), Microsporum spp. (M. canis, M. gypseum) and Epidermophyton floccosum.
– Heavy, common ringworm smooth skin of the trunk and limbs requiring systemic treatment.
– Candidiasis of the skin and mucous membranes.
Hypersensitivity to the active substance or to any of the excipients;
acute or chronic liver disease;
Children under 2 years of age (efficacy and safety have not been established)
during lactation. Precautions: pregnancy; renal failure; alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease.
Application of pregnancy and lactation
on the safety of terbinafine Data in pregnancy is not. Therefore anadrol cycle should be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus. LactationTerbinafine is excreted in breast milk. Its use during breastfeeding is contraindicated.
DOSAGE AND ADMINISTRATION
The duration of treatment and dosage regimen set individually and depend on the process of localization and severity of the disease. Adults: Inside, after a meal. The usual dose is 250 mg 1 time per day.Onychomycosis: duration of treatment on average 6-12 weeks. With the defeat of nails of fingers and feet (with the exception of the big toe), or the young age of the patient treatment duration may be less than anadrol cycle 12 weeks.